Tag Archives: biotage

Biotage® ACT Plate Adapter Prevents Evaporative Cross-Talk

July 26, 2015 staronepr Leave a comment

Biotage® (STO: BIOT), announces the launch of Biotage® ACT (Anti Cross Talk) Plate Adapter, an innovative solution for prevention of well to well cross contamination during extract evaporation.

Uppsala, Sweden — Biotage® (STO: BIOT), a leading global supplier of solutions and technology for analytical and medicinal chemistry, announces the launch of Biotage® ACT (Anti Cross Talk) Plate Adapter, an innovative solution for prevention of well to well cross contamination during extract evaporation.

Biotage® ACT Plate Adapter is an essential accessory for evaporation devices. Constructed from robust, high grade anodized aluminum, it fits on top of the 96-well collection plate containing the sample during evaporation. The plate adapter is compatible with straight needle evaporation devices such as the Biotage® SPE Dry 96 and Biotage® SPE Dry Dual systems, and does not require any changes to the existing analytical method.

The Biotage® ACT Plate Adapter is designed to fit on top of the 96-well collection plate, is reusable and easy to use. Evaporated gases are directed away from the sample wells, eddies are reduced, and the plate adapter reduces the open surface area of the top of the wells, lessening the likelihood that material can re-enter and contaminate adjacent wells.

“During evaporation a proportional amount of analytes present in an extracted sample can contaminate surrounding wells by being carried with the volatilized solvent. If the analyte concentration in one well is considerably higher than the analyte concentration in the surrounding wells it has the potential to cause a clinically significant and erroneous change to the adjacent samples. Biotage® ACT Plate Adapter is the first commercially available device to address the issue of cross talk on evaporation” says Dr. Claire Desbrow, Product Manager, Analytical Chemistry, Biotage.

The plate adapter can be incorporated into existing assays without the need for changing any other aspects of the method, and there is minimal impact of solvent drying times.

For further information, visit http://www.biotage.com or call:
In Europe: +46 18 56 57 10
In North America: (Toll Free) 1 800 446 4752
In Japan: +81 422 28 1233
Other areas, please call: +46 18 56 57 10

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For further press information at Biotage, please contact:
James Churchill
Marketing Communications
Biotage GB Limited
Distribution Way
Dyffryn Business Park
Ystrad Mynach
Hengoed, Wales CF82 7TS
United Kingdom
Tel: +44 (0)1443 811 849
Mobile: +44(0)7875484778
Email: james.churchill@biotage.com

About Biotage
Biotage offers solutions, knowledge and experience in the areas of analytical and medicinal chemistry. Customers include the world’s top pharmaceutical and biotechnology companies, as well as leading academic institutes. The company is headquartered in Uppsala, Sweden, with offices in China, Japan, the United Kingdom, the United States and a worldwide network of distributors. Biotage has 293 employees with sales of 490 MSEK in 2014. Biotage is listed on the NASDAQ OMX Nordic Stock Exchange. Website: http://www.biotage.com.

Biotech

Biotage® Announces EVOLUTE® EXPRESS Columns – Simplified, Fast and Efficient SPE using the Load-Wash-Elute Procedure

June 26, 2015 staronepr Leave a comment

Biotage® (STO: BIOT), announces the addition of new polymer based SPE columns to their tried and tested EVOLUTE® EXPRESS range.

Uppsala, Sweden (June 26, 2015) — Biotage® (STO: BIOT), a leading global supplier of solutions and technology for analytical and medicinal chemistry, announces the addition of new polymer based SPE columns to their tried and tested EVOLUTE® EXPRESS range.

EVOLUTE® EXPRESS is a novel family of plates, and now columns, that simplify polymer-based SPE by employing a streamlined three step protocol; Load-Wash-Elute. By using this approach and removing the conditioning and equilibration steps, necessary with traditional bio-analytical SPE procedures, processing and method development times are dramatically reduced without loss of analyte recovery or method robustness.

The EVOLUTE® EXPRESS design provides a uniform flow in the processing of aqueous samples and eliminates the need for re-runs due to clogging. This clear flow technology makes EVOLUTE® EXPRESS particularly efficient and effective when used with SPE automated systems, (such as the Biotage Extrahera™) and enabling consistent, rapid and reliable manual processing.

“Biotage has built a reputation for offering products that simplify Sample Preparation, promoting high throughput and reliability. By expanding the tried and tested EVOLUTE® EXPRESS range we address a real concern for many analysts who have to re-run samples due to well-clogging and sample variability. The minimal three step approach of Load-Wash-Elute considerably improves the way SPE is performed and offers significant time savings for all bio-analysis labs” says Dr. Claire Desbrow, Analytical Chemistry, Product Manager, Biotage.

EVOLUTE® EXPRESS columns are packed with polymer-based EVOLUTE® chemistries (ABN, CX, WCX, AX and WAX) to address most application needs in a wide range of laboratories.

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Biotech

New Biotage® SNAP ULTRA C18 Cartridges – High Performance Reversed Phase Flash Purification

November 11, 2014 staronepr Leave a comment

Biotage announces the launch of Biotage® SNAP ULTRA C18 – a range of high performance, reversed phase flash purification cartridges and samplets.

Uppsala, Sweden (November 11, 2014) — Biotage (STO: BIOT), a leading global supplier of solutions and technology for analytical, medicinal and peptide chemistry, announces the launch of Biotage® SNAP ULTRA C18 – a range of high performance, reversed phase flash purification cartridges and samplets.

Biotage® SNAP ULTRA C18 reversed phase cartridges are optimized for use with Biotage ACI™ and Isolera™ flash systems and are available in 12 g, 30 g, 60 g, 120 g, 400 g, 950 g and 1850 g cartridge sizes. They enable chemists to confidently load 2-3% weight percentage of samples onto reversed phase columns, a marked improvement when compared to the currently typical 0.5 – 1% loads. The time taken for purification and solvent usage can therefore be reduced by 50% or a smaller cartridge can be used for the same purification, often with improved purification results.

The new reversed phase cartridges are packed with the new, Biotage® HP-Sphere C18 25 micron spherical silica particles that give a boost to resolution with higher purity peaks over standard reversed phase cartridges. The silica is chemically neutral with no adverse interactions, ensuring higher yields and better recoveries; a wide diversity of purifications are possible, including the use of both acidic or basic modifiers.

“It is no longer enough for suppliers to arbitrarily work on single aspects of the workflow and purification – today a more holistic approach is required, one that involves a combination of factors; with this product range we have further augmented the Biotage ACI™ and Isolera™ flash systems and have created a superior product for purification” says Dr. Sunil Rana, Global Product Manager, Biotage.

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About Biotage
Biotage offers solutions, knowledge and experience in the areas of analytical and medicinal chemistry. Customers include the world’s top pharmaceutical and biotechnology companies, as well as leading academic institutes. The company is headquartered in Uppsala, Sweden, with offices in China, Japan, the United Kingdom, the United States and a worldwide network of distributors. Biotage has 290 employees with sales of 444.6 MSEK in 2013. Biotage is listed on the NASDAQ OMX Nordic Stock Exchange. Website: http://www.biotage.com.

Biotech

Biotage Launches ACI™ – Accelerated Chromatographic Isolation

July 11, 2014 staronepr Leave a comment

Biotage announces the launch of ACI™ (Accelerated Chromatographic Isolation), a new advance converting simple flash purification into a faster and more economical way to isolate pure compounds.

Uppsala, Sweden (July 10, 2014) — Biotage (STO: BIOT), a leading global supplier of solutions and technology for analytical, medicinal and peptide chemistry, announces the launch of ACI™ (Accelerated Chromatographic Isolation), a new advance converting simple flash purification into a faster and more economical way to isolate pure compounds.

Biotage believes that ACI™ will radically improve the efficiency of the laboratory, embracing the latest developments in purification technology to guide chemists towards improved chromatography. With running costs a concern in most laboratories, ACI™ will efficiently move users to the end-point even faster. Traditional purification taking more than 15 minutes is reduced to 5 minutes; a 250 mg scale laboratory scale experiment can now be purified in less than 3 minutes on a 10 g column with an ACI™ enabled Biotage Isolera™ flash purification system.

“This is a very exciting and pivotal development, the speed enhancements are akin to the impact felt when microwaves first hit the scene. There is nothing out there that comes close to this system. Chemists will now have freedom to work on other things while they let their ACI™ system do the purification. It is fully automated, reliable and lightning fast, we can completely purify 250 mg of sample in less than 3 minutes, this is quicker than most people take to run the TLC” says Dr Sunil Rana, Global Product Manager, Biotage.

Biotage Isolera™ systems already recommend cartridges based on the sample size and programmed TLC data; they work out the best solvent gradient based on compound, and provide real time indication of eluting compounds, using UV, ELSD or Mass Detection. They subtract signal baselines automatically, so chemists can be confident that the correct fractions are collected.

ACI™ radically improves this, working seamlessly with the Biotage Isolera™ system, the simple wizard quickly guides chemists through the system, beneficial for new users or those whose expertise or priorities lie in synthesis rather than purification. Existing Biotage Isolera systems can be upgraded to ACI™ systems, and ACI™ will come as standard on all new production systems.

For further information visit http://www.biotage.com or call:
In Europe: +46 18 56 57 10
In North America: (Toll Free) 1 800 446 4752
In Japan: +81 422 28 1233
Other areas, please call: +46 18 56 57 10

-Ends-

For further press information from Biotage please contact:
James Churchill
Marketing Communications
Biotage GB Limited
Distribution Way
Dyffryn Business Park
Ystrad Mynach
Hengoed, Wales CF82 7TS
United Kingdom
Tel: +44 (0)1443 811 849
Mobile: +44(0)7875484778
E-Mail: james.churchill@biotage.com

About Biotage
Biotage offers solutions, knowledge and experience in the areas of analytical and medicinal chemistry. Customers include the world’s top pharmaceutical and biotechnology companies, as well as leading academic institutes. The company is headquartered in Uppsala, Sweden, with offices in China, Japan, the United Kingdom, the United States and a worldwide network of distributors. Biotage has 290 employees with sales of 444.6 MSEK in 2013. Biotage is listed on the NASDAQ OMX Nordic Stock Exchange. Website: http://www.biotage.com.

Biotech

New 1 mL ISOLUTE® SLE+ 48-well Plates from Biotage – Extract Larger Sample Volumes, Faster

July 1, 2014 staronepr Leave a comment

Biotage announces the launch of the new ISOLUTE® SLE+ 1 mL Supported Liquid Extraction 48-well plates, enabling the extraction of larger sample volumes (1 mL total load volume) than presently possible in the microplate footprint.

Uppsala, Sweden (June 30, 2014) — Biotage (STO: BIOT), a leading global supplier of solutions and technology for analytical, medicinal and peptide chemistry, announces the launch of the new ISOLUTE® SLE+ 1 mL Supported Liquid Extraction 48-well plates, enabling the extraction of larger sample volumes (1 mL total load volume) than presently possible in the microplate footprint.

The new ISOLUTE® SLE+ 1 mL sample volume 48-well plates are packed with ISOLUTE SLE+ material; each well containing sufficient ISOLUTE® SLE+ material to efficiently extract 1 mL of aqueous sample. Existing 96-well formats have a maximum capacity of 400 µL, the new plates enable customers to extract larger sample volumes and therefore achieve higher sensitivity, higher throughput and lower detection limits.

The new plates are ideal for the extraction of small molecule drugs, metabolites and endogenous biomarkers from biological fluid samples prior to analytical techniques such as LC-MS/MS and GC-MS. Analytical chemists in clinical, forensic toxicology and Pharmacology will appreciate the high throughput and extra sample capacity.

As with the other products in the ISOLUTE® SLE+ range, the same simple load-wait-elute procedure is used with this new 48-well format reducing method development time.

The plates can be processed using microplate compatible positive pressure manifolds, such as the Biotage® Pressure+ 96, vacuum manifolds such as the Biotage® VacMaster™ 96 and most automated liquid handling systems.

The plate is arranged in a 6 x 8 array; with 48 samples being processed per plate a higher throughput than equivalent column formats is achievable. A new compatible 48-well collection plate is also available with a 5 mL capacity so that the entire elution solvent volume can be collected with no need to swap collection vessels.

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About Biotage
Biotage offers solutions, knowledge and experience in the areas of analytical and medicinal chemistry. Customers include the world’s top pharmaceutical and biotechnology companies, as well as leading academic institutes. The company is headquartered in Uppsala, Sweden, with offices in China, Japan, the United Kingdom, the United States and a worldwide network of distributors. Biotage has 290 employees with sales of 444.6 MSEK in 2013. Biotage is listed on the NASDAQ OMX Nordic Stock Exchange. Website: http://www.biotage.com.

Biotech

Biotage Breaks New Ground with Its Fully Integrated Mass Directed Flash System

June 6, 2013 staronepr Leave a comment

Biotage announces the launch of the new Isolera™ Dalton – a fully automated miniaturized mass directed flash purification system.

Uppsala, Sweden, June 5, 2013 — Biotage (STO: BIOT), a leading global supplier of solutions and technology for analytical, medicinal and peptide chemistry, announces the launch of the new Isolera™ Dalton – a fully automated miniaturized mass directed flash purification system. The new system raises the bar for flash purification by integrating, for the first time, a miniaturized mass detector and an advanced flash chromatography system into one commercially available platform.

The mass detector and Isolera™ Spektra flash purification system are seamlessly integrated via the Isolera™ Dalton Nanolink unit, an intelligent sampling device which handles all fluids and synching calculations between the two units. Isolera™ Dalton easily fits inside a standard fume hood, requires no external pumps and is capable of both normal and reverse-phase separations, so it is completely compatible with the diverse purification needs of the modern research laboratory.

“Compounds are identified in real time during purification and this informs the flash fractionation process, enabling the correct product to be collected by the system. The system automatically accommodates different column sizes and flow rates, overcoming major issues with simple splitter-based systems. Isolera™ Dalton significantly reduces the number of steps required to purify and confirm a target compound, thus improving workflow and increasing confidence that chemists have synthesized what was intended. Quite frankly there is nothing else like it on the market today or that even comes close”
says Dr Sunil Rana, Global Product Manager, Biotage.

The instrument uses a wizard-based approach to method development, simple on screen prompts guides chemists through the system; even those whose expertise or priorities lie in compound synthesis rather than analysis.

-Ends-

For further press information at Biotage please contact:
James Churchill
Marketing Communications
Biotage GB Limited
Distribution Way
Dyffryn Business Park
Ystrad Mynach
Hengoed, Wales CF82 7TS
United Kingdom
Tel: +44 (0)1443 811 849
Mobile: +44(0)7875484778
E-Mail: james.churchill@biotage.com

About Biotage
Biotage offers solutions, knowledge and experience in the areas of analytical chemistry, medicinal chemistry, separation and purification. The customers include pharmaceutical and biotech companies, companies within the food industry and leading academic institutes. The company is headquartered in Uppsala and has offices in the US, UK, China and Japan. Biotage has approx. 290 employees and had sales of 463 MSEK in 2012. Biotage is listed on the NASDAQ OMX Nordic Stockholm stock exchange. Website: http://www.biotage.com.

Biotech

ISOLUTE® Myco SPE Columns, a Dedicated Product for The Efficient Extraction of Mycotoxins from Food Matrices

April 16, 2013 staronepr Leave a comment

Biotage has announced the launch of ISOLUTE® Myco SPE columns, a new product for the ‘catch and release’ clean up of mycotoxins from food matrices, prior to analysis by LC-MS/MS.

Uppsala, Sweden, April 16, 2013 — Biotage (STO: BIOT), a leading global supplier of solutions and technology for analytical, medicinal and peptide chemistry, has announced the launch of ISOLUTE® Myco SPE columns, a new product for the ‘catch and release’ clean up of mycotoxins from food matrices, prior to analysis by LC-MS/MS.

The ISOLUTE® Myco sorbent is a proprietary polymeric phase (patent pending) optimized for the extraction of a broad spectrum of mycotoxins from a wide range of foodstuffs; enabling chemists to utilize a single SPE product to extract all relevant mycotoxins from an individual foodstuff. Using a single, easy to use sample preparation product, along with optimized matrix specific application notes, scientists can prepare diverse samples for analysis by LC-MS/MS.

ISOLUTE® Myco SPE columns have been developed for use together with LC-MS/MS analysis, their selective clean up enables robust, reliable quantitation of mycotoxins without compromising analytical data quality. The coupling of a dedicated polymer based sorbent with LC-MS/MS analysis saves both time and money as more samples can be processed each day compared to IAC based clean up. The tabless 3 mL format of the ISOLUTE® Myco columns is suitable for a variety of processing equipment including vacuum manifolds, positive pressure manifolds and automated SPE workstations.

“ISOLUTE® Myco SPE columns are a real step forward in mycotoxin sample preparation, helping scientists to fully exploit the advantages of higher productivity and highly selective LC-MS/MS analysis through the use of a truly optimized sample preparation regime” says Dr. Claire Desbrow, Global Product Manager.

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About Biotage
Biotage offers solutions, knowledge and experience in the areas of analytical and medicinal chemistry. Customers include the world’s top pharmaceutical and biotechnology companies, as well as leading academic institutes. The company is headquartered in Uppsala, Sweden, with offices in China, Japan, the United Kingdom, the United States and a worldwide network of distributors. Biotage has 272 employees with sales of 462.9 MSEK in 2012. Biotage is listed on the NASDAQ OMX Nordic Stock Exchange. Website: http://www.biotage.com.

Biotech

Biotage® announces EVOLUTE® EXPRESS 96-well plates; simplified, fast and efficient SPE using the Load-Wash-Elute procedure

September 26, 2012 staronepr Leave a comment

Biotage® (STO: BIOT), introduced EVOLUTE® EXPRESS, a novel family of 96-well plates that simplify polymer-based SPE by employing a streamlined 3-step protocol; Load-Wash-Elute.

Uppsala, Sweden, September 26, 2012 — Biotage® (STO: BIOT), a leading global supplier of solutions and technology for analytical and medicinal chemistry, introduced EVOLUTE® EXPRESS, a novel family of 96-well plates that simplify polymer-based SPE by employing a streamlined 3-step protocol; Load-Wash-Elute. By using this novel approach and removing the conditioning and equilibration steps, necessary with traditional bio-analytical SPE procedures, processing and method development times are dramatically reduced without loss of analyte recovery or method robustness.

The EVOLUTE® EXPRESS design provides a uniform flow in the processing of aqueous samples and eliminates the need to re-run samples due to well-clogging. This clear flow technology makes EVOLUTE® EXPRESS particularly efficient and effective when used with SPE automated systems whilst adding a distinct advantage by allowing consistent, rapid and reliable manual processing of the plates.

“Biotage has built a reputation for offering products that simplify Sample Preparation, promoting high throughput and reliability. This new product addresses a real concern for many analysts who have to re-run samples due to well-clogging and sample variability. The minimal 3-step approach of Load-Wash-Elute will considerably improve the way SPE is performed and offer significant time savings for all bio-analysis labs” says Gavin Jones, Sample Preparation Product Manager, Biotage.

EVOLUTE® EXPRESS 96-well plates are packed with polymer-based EVOLUTE® chemistries (ABN, CX, WCX, AX and WAX) to address most application needs, and a new sorbent selection plate for screening and method development has been added.

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About Biotage
Biotage offers solutions, knowledge and experience in the areas of analytical and medicinal chemistry. Customers include the world’s top pharmaceutical and biotechnology companies, as well as leading academic institutes. The company is headquartered in Uppsala, Sweden, with offices in China, Japan, the United Kingdom, the United States and a worldwide network of distributors. Biotage has 272 employees with sales of 428.9 MSEK in 2010. Biotage is listed on the NASDAQ OMX Nordic Stock Exchange. Website: http://www.biotage.com.

Biotech

Biotage Moving Into Mass Directed Flash

September 25, 2012 staronepr Leave a comment

Biotage® (STO: BIOT), announces that Biotage is in late stage development with its partner Microsaic Systems plc of a fully integrated solution for Mass Directed Flash with Biotage’s flagship flash purification system Isolera™.

Uppsala, Sweden, September 25, 2012 — Biotage® (STO: BIOT), a leading global supplier of solutions and technology for analytical, medicinal and peptide chemistry, announces that Biotage is in late stage development with its partner Microsaic Systems plc of a fully integrated solution for Mass Directed Flash with Biotage’s flagship flash purification system Isolera™. A presentation will be held at the JASIS meeting in Makuhari, Japan on 5th September, 2012. The new solution will become commercially available in early 2013.

“This is a game changer in flash purification that will allow chemists to significantly improve their work flow. We have high expectations on the forthcoming launch of this product that will further strengthen our purification business,” says Toshiyuki Yachi, Vice President of Marketing.

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About Biotage
Biotage offers solutions, knowledge and experience in the areas of analytical and medicinal chemistry. Customers include the world’s top pharmaceutical and biotechnology companies, as well as leading academic institutes. The company is headquartered in Uppsala, Sweden, with offices in China, Japan, the United Kingdom, the United States and a worldwide network of distributors. Biotage has 272 employees with sales of 428.9 MSEK in 2010. Biotage is listed on the NASDAQ OMX Nordic Stock Exchange. Website: http://www.biotage.com.

Biotech

Biotage Unveils New Fully Automated Microwave Peptide Synthesizer

September 25, 2012 staronepr Leave a comment

Biotage® (STO: BIOT), introduced an innovative new synthesis platform for peptide researchers at the 2012 European Peptide Symposium in Athens, Greece.

Uppsala, Sweden, September 25, 2012 — Biotage® (STO: BIOT), a leading global supplier of solutions and technology for analytical, medicinal and peptide chemistry, introduced an innovative new synthesis platform for peptide researchers at the 2012 European Peptide Symposium in Athens, Greece. The Biotage® Initiator+ Alstra is a fully automated, single channel, programmable microwave peptide synthesizer and is the latest addition to Biotage’s growing family of peptide synthesis platforms.

The Initiator+ Alstra is an ideal tool for peptide chemists synthesizing peptides, peptoids, PNA and peptidomimetics, including extremely difficult modifications. The system’s inherent flexibility for reagent set-up, makes it a highly effective platform for both small and large scale synthesis from 5 µmol to 2 mmol. With a working volume from as low as 0.6 mL, the Initiator+ Alstra is perfectly suited for small scale microwave peptide synthesis, especially when the use of expensive building blocks is required e.g. PNA. The system’s robotic liquid handler and precise digital syringe pumps reduce reagent and solvent consumption, thus reducing cost and minimizing waste.

The Initiator+ Alstra is programmable via a large 10″ touch screen with drag and drop functionality for optimizing pre-installed or user defined methods. A built-in wizard makes programming a synthesis sequence effortless and a calculation table, which is generated, provides the quantities of reagents required, allowing the user to very quickly go from an idea to execution.

“Initiator+ Alstra is an extremely simple to use work horse which fills an important gap in the toolbox of the Peptide researcher. Its state of the art interface, simplicity of operation, speed, size and price are all optimized to match the increasing demands which Peptide Chemists are under today”, say’s Dr. Amit Mehrotra, Peptide Product Manager at Biotage. “This product is the result of customer input and demands and we are very excited to now be putting it into their hands”.

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About Biotage
Biotage offers solutions, knowledge and experience in the areas of analytical and medicinal chemistry. Customers include the world’s top pharmaceutical and biotechnology companies, as well as leading academic institutes. The company is headquartered in Uppsala, Sweden, with offices in China, Japan, the United Kingdom, the United States and a worldwide network of distributors. Biotage has 272 employees with sales of 428.9 MSEK in 2010. Biotage is listed on the NASDAQ OMX Nordic Stock Exchange. Website: http://www.biotage.com.